Effective salvage treatment of recurrent Ewing sarcoma utilizing chemotherapy and zoledronic acid.

نویسندگان

  • Tariq Siddiqui
  • Robert de Wilton Marsh
  • Carmen Allegra
  • Denise Whittaker
  • Mark Scarborough
  • Parker Gibbs
  • Robert Zlotecki
  • John David Reith
  • Walter Drane
چکیده

Tariq Siddiqui, MD1, Robert de Wilton Marsh, MD1, Carmen Allegra, MD1, Denise Whittaker, PA1, Mark Scarborough, MD2, Parker Gibbs, MD2, Robert Zlotecki, MD3, John David Reith, MD4, and Walter Drane, MD5 1Division of Hematology/Oncology, 2Division of Orthopedic Oncology, 3Department of Radiation Oncology, 4Department of Pathology, 5Department of Nuclear Medicine College of Medicine, University of Florida, Gainesville, Florida

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

sCD30 and sCD40L Detection in Patients with Osteosarcoma, Chondrosarcoma and Ewing Sarcoma

Background: Primary malignant bone tumors are heterogeneous groups of neoplasms, which affect mainly children and adolescents. The most common types are Osteosarcoma, Ewing sarcoma and chondrosarcoma. Elevation of sCD30 and sCD40L has been observed in lymphoma, leukemia and autoimmune disorders. Objective: To evaluate serum concentrations of sCD30 and sCD40L in patients with primary malignant b...

متن کامل

In vitro antitumor effect of sodium butyrate and zoledronic acid combined with traditional chemotherapeutic drugs: a paradigm of synergistic molecular targeting in the treatment of Ewing sarcoma.

Histone deacetylase inhibitors and bisphosphonates have a promising future in the treatment of cancer as targeted anticancer drugs, particularly when used together or in combination with other cytotoxic agents. However, the effects of these combined treatments have not yet been systematically evaluated in Ewing sarcoma. The in vitro effects on cellular proliferation, viability and survival were...

متن کامل

Current Therapeutic Approaches in Metastatic and Recurrent Ewing Sarcoma

Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches...

متن کامل

Primary Extraosseous Ewing Sarcoma of the Maxillary Sinus in an Adult-A Rare Case Report

Introduction: Ewing sarcoma (ES), which is described as diffuse endothelioma of the bone, is divided into osseous and extraosseous Ewing sarcoma (EES) mostly affecting children and adolescents. It is a rare, aggressive, and poorly differentiated small blue round cell tumor that seldom affects the head and neck regions.   Case Report: Herein, we reported a 46-year-old ma...

متن کامل

Short Term Complications and Functional Results of Sarcoma Limb Salvage Surgeries

Background: Limb salvaging surgeries are current surgical treatment of extremity bone sarcomas. Resected bonereplacement consists of two main methods; tumor prosthesis versus structural allograft. Biological reconstruction withan allograft is an economic cheap method in young sarcoma patients, however, the surgeons are more convinced withtumor prosthesis replacement.Methods: We evaluated the sh...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Clinical advances in hematology & oncology : H&O

دوره 8 7  شماره 

صفحات  -

تاریخ انتشار 2010